Bothell Office

(425) 402-4787

Monroe Office

(425) 402-4787

Erectile Dysfunction

What Is Erectile Dysfunction?

Sexual dysfunction caused by the inability to develop or maintain an erection of the penis during sexual performance.1

Causes:

ED is usually multifactorial, but is typically caused by psychological  causes or vascular disease. Some causes include:

  • Psychological - depression, performance anxiety, stress
  • Lifestyle - tobacco or illicit drug use, excessive alcohol consumption, lack of exercise
  • Medical Conditions - epilepsy, neurologic disease, spinal cord injury, atherosclerosis, peripheral vascular disease, hypogonadism, diabetes, thyroid disease, hypertension, hyperlipidemia, chronic disease, trauma or injury, benign prostatic hyperplasia or penile plaques/ scarring and some medications1

How do Erections Occur?

  • Erections occur due to response to stimuli
  • Stimulation causes a release of nitric oxide synthase which stimulates nitric oxide production
  • This produces cyclic guanosine monophosphate (cGMP) and cyclic adenosine monophosphate (cAMP), which relaxes the smooth muscle in the arteries of the erectile tissue, therefore increasing blood flow and causing erection 
  • PDE5 inhibitors (tadalafil, sildenafil) work on the conversion of cGMP to GTP which causes flaccidity allowing for an erection to occur1,2

Citation

Treatment Options 

  • PDE5 Inhibitors - Examples include tadalafil (Cialis) or sildenafil (Viagra)
    • Tadalafil is taken daily while sildenafil is taken 60 minutes before sexual activity
  • Testosterone Replacement Therapy (TRT)
  • Regenerative Therapies, such as stem cells1

Potential Side Effects of PDE5 Inhibitors 

  • Common: muscle aches in the back (resolve in a few weeks, diarrhea, headache, myalgias, flushing and dyspepsia
  • Rare: severe hypotension, stroke, vision or hearing loss, seizures or priapism
  • These cannot be taken with nitrates1

Contact us at [email protected] or call 425-402-4787 to schedule a free consultation. 

Locations

Bothell Regenerative Medicine


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18920 Bothell Way NE # 100, Bothell, WA 98011

14090 Fryelands Blvd #274, Monroe, WA 98272

(425) 402-4787